The enzyme PIP5K1C controls the activity of cellular receptors that signal pain, researchers have found. By reducing the enzyme, researchers showed that levels of a lipid called PIP2 is also lessened. They also found a compound that can dampen the activity of PIP5K1C. These findings could lead to a new kind of pain reliever for the more than 100 million people who suffer from chronic pain in the US....
The craft of opposition research—finding information that might put an opponent in a negative light—has long been a staple of political campaigns. This year, independent groups are taking a leading role....
Cynthia Quarterman, a top U.S. safety regulator tasked with handling the U.S. government's response to a string of oil-train crashes in recent years, is stepping down....
The Los Angeles City Council has approved one of the nation's highest minimum wages for workers at the city's large hotels....
The U.S. government will pay the Navajo Nation $554 million to settle long-standing claims that it mismanaged funds and natural resources on the tribe's reservation for years....
Connecticut gubernatorial candidate Joe Visconti opposes the state's new gun restrictions, and he has an online commercial that shows him riding in a 1974 Pontiac convertible with rifles fixed to the rear fenders. ...
The U.S. and Arab allies launched a second major wave of airstrikes in Syria targeting mobile oil refineries controlled by Islamic State, the Pentagon said....